Amgen
Affiliate(s):
Japan Tobacco
Lonza Biologics (terminated 6/03)
Takeda Pharmaceutical Company


Current as of: Feb-12-2010  

Generic Name: Panitumumab
Brand Name: Vectibix
Other Designation: ABX-EGF (formerly known as clone E7.6.3)
Panitumumab is a fully human IgG2 monoclonal antibody (MAb) targeting the epidermal growth factor receptor (EGFr).

Epidermal growth factor (EGF) receptor (EGFr, ErbB-1, ErbB1, HEr-1, HEr1)

• colorectal cancer expressing the epidermal growth factor receptor (EGFr), metastatic, refractory, third line
• colorectal cancer, metastatic, refractory to fluoropyrimidine, oxaliplatin, and irinotecan-containing chemotherapy regimens, third line, expressing EGFr with non-mutated K-ras

GlaxoSmithKline
Affiliate(s):
University of Florida Gainsville


Current as of: Feb-5-2010  

Generic Name: Topotecan
Brand Name: Hycamtin, Hycaptamine
Other Designation: NSC-609699, SK&F-104864
Topotecan, a water-soluble camptothecin analog, is a topoisomerase I inhibitor.

Topoisomerase I

• ovarian cancer, metastatic, second or third line-IV
• small cell lung cancer (sclc), refractory, second line treatment-IV
• small cell lung cancer (sclc), relapsed, when retreatment with the first line regimen is not considered appropriate, IV
• cervical cancer, Stage IVb recurrent or persistent not amenable to curative treatment with surgery and/or radiation therapy, in combination with cisplatin-IV
• small cell lung cancer (sclc), relapsed-PO